The benefits of alpha-lipoic acid are well documented. It helps control
diabetic neuropathy as well as increase insulin sensitivity and glucose
disposal. The one drawback, when taken in oral form, has been how
quickly it is cleared out of the system. In fact, the plasma half-life
is 28 minutes. Increasing the time in plasma (TIP) is the novel feature
of NutraVene CR-ALA
Lowest Price on the Internet! $42.00 Click here to view the NutraVene CR-ALA label
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NutraVene CR-ALA is a proprietary, orally active, controlled-release formulation of alpha-lipoic acid manufactured and distributed by NutraVene, San Francisco CA. Alpha-Lipoic acid is produced naturally in human cells where it functions as a coenzyme that contributes to oxidative glucose metabolism. NutraVene CR-ALA Benefits
NutraVene CR-ALA Features
NutraVene CR-ALA Advantage The primary advantage of the NutraVene CR-ALA formulation is that it increases the length of time in plasma of alpha-lipoic acid (several hours). This provides NutraVene CR-ALA with a pharmacokinetic advantage that is a marked improvement over other alpha-lipoic acid products in which alpha-lipoic acid is rapidly cleared, usually within 30 minutes (2). Controlled-release technology is what makes NutraVene CR-ALA appropriate for use as a potent oxidative stress antagonist. Oxidative stress, and specifically its imbalance with antioxidant depletion, is associated with neuropathy. Recommended Dosing Take 2 tablets in the morning and 1 tablet in the evening on an empty stomach at least 30 minutes before intake of food, or as directed by your health care professional. Contraindications NutraVene CR-ALA is contraindicated in individuals with known hypersensitivity to alpha-lipoic acid or other sulfur-containing compounds. NutraVene CR-ALA is contraindicated in individuals that are thiamin deficient. Interactions There are no known drug interactions with alpha-lipoic acid.
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Unlocking the Potential of ALA The benefits of alpha-lipoic acid are well documented. It helps control diabetic neuropathy as well as increase insulin sensitivity and glucose disposal. The one drawback, when taken in oral form, has been how quickly it is cleared out of the system. In fact, the plasma half-life is 28 minutes. Increasing the time in plasma (TIP) is the novel feature of NutraVene CR-ALA. NutraVene CR-ALA: Maintaining Therapeutic Plasma Levels of ALA NutraVene CR-ALA was invented to mimic the sustained therapeutic levels of ALA in plasma. A patented controlled-release (sustained-release) technology was applied. The result was achieving a five-fold magnification in plasma time of ALA. Clinical trials were then run to test for safety and efficacy. An IRB-approved human study on the effect of NutraVene CR-ALA on type II diabetics has now been completed. The results are published in Endocrine Practice Vol. 8, No. 1 January/February. Patients received 12 weeks of active treatment, 900 mg/day for 6 weeks and 1200 mg/day for 6 weeks. Subjects remained on existing anti-hyperglycemic medications. They were monitored on a regular basis for glucose and lipid control, liver enzymes, and other clinical markers. The results are as follows:
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Managing diabetes means controlling blood sugar. That’s why diet and exercise are prescribed by practically every doctor and diabetic educator. Yet there’s a growing frustration in the medical community at the lack of effective adjunct treatments in helping to stabilize blood sugar levels. Doctors acknowledge that they simply do not have enough tools. And they certainly understand the consequence. Today’s fluctuating blood-sugar levels are tomorrow’s diabetic complications. But there’s some good news. Recent clinical studies have demonstrated that a safe and natural compound, alpha-lipoic acid, helps improve insulin sensitivity and glucose utilization. Effects of NutraVene CR-ALA on Insulin Sensitivity (IS) and Glucose Metabolism (GM) Several double-blind placebo-controlled clinical studies now point to alpha-lipoic acid’s beneficial effect on blood sugar control. In one study, 20 subjects were given 500 mgs of alpha-lipoic acid for a period of 10 days. The insulin-stimulated glucose disposal and insulin sensitivity increased by 30%. The result was considered statistically significant (p<.05). In clinical terms, that means the improvement could not be attributed to any other factor(s) except the alpha-lipoic acid. Effects of NutraVene CR-ALA on Muscle Uptake of Glucose in Type II Diabetics The majority of glucose is stored in skeletal muscle tissue.
That’s because skeletal muscle constitutes the bulk of body
tissue. Any defect in the uptake of glucose by muscle
contributes significantly to Type 2 diabetes, glucose
intolerance, and sub-clinical hyperglycemia. |